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What is a VIPoma?
A VIPoma or vipoma ( / vɪˈpoʊmə /) is a rare endocrine tumor that overproduces vasoactive intestinal peptide (thus VIP + -oma ). The incidence is about 1 per 10,000,000 per year. VIPomas usually (about 90%) originate from the non-β islet cells of the pancreas.
What is the incidence of VIPomas in the US?
The incidence is about 1 per 10,000,000 per year. VIPomas usually (about 90%) originate from the non-β islet cells of the pancreas. They are sometimes associated with multiple endocrine neoplasia type 1.
Is there a cure for VIPoma?
Some people seem to respond to a combination chemo called capecitabine and temozolomide but there is no report that it totally cured people of VIPoma. Surgery can usually cure VIPomas. However, in one-third to one-half of patients, the tumor has spread by the time of diagnosis and cannot be cured.
What is a VIPoma of the pancreas?
A vipoma is a non-beta pancreatic islet cell tumor secreting vasoactive intestinal peptide (VIP), resulting in a syndrome of watery diarrhea, hypokalemia, and achlorhydria (WDHA syndrome). Diagnosis is by serum VIP levels. Tumor is localized with CT and endoscopic ultrasound. Treatment is surgical resection.
Summary Summary. A VIPoma is a rare cancer caused by a type of pancreatic neuroendocrine tumor, which is tumor that arises from cells that produce hormones – allowing the tumor itself to produce hormones.
What is the prognosis of VIPomas?
The median survival of people with VIPomas is 96 months, but long-term survival mainly depends on the tumor grade, staging, and whether all or most of the tumor can be removed. [3] This table lists symptoms that people with this disease may have.
What happens if you have a VIPoma in Your Lung?
For a VIPoma in your lung, your surgeon removes the tumour and checks for other tumours. You might just have the tumour removed. Or you may need to have part of the lung removed. Cancer cells have changes in their genes (DNA) that make them different from normal cells.
What are the diagnostic criteria for VIPoma?
Diagnosis of VIPoma is made in patients with secretory diarrhea usually greater than 3.0 liters per day with a serum VIP level around 250 to 500 pg/ml (reference range is less than 190 pg/ml). Secretory diarrhea has a low fecal osmotic gap of less than 50 mOsm/kg.