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What is pyoderma gangrenosum (PG)?
Pyoderma gangrenosum (PG) is a complex neutrophilic dermatosis that can occur as an idiopathic disease, in association with systemic conditions such as inflammatory bowel disease, as part of an inherited inflammatory syndrome.
Who is most at risk for pyoderma gangrenosum?
People who have certain underlying conditions, such as inflammatory bowel disease or arthritis, are at higher risk of pyoderma gangrenosum. Pyoderma gangrenosum ulcers can develop quickly.
What is the relationship between pyoderma gangrenosum and ulcerative colitis?
Pyoderma gangrenosum is associated with ulcerative colitis in 5% to 12% of cases and is associated with Crohn disease in 1% to 2% of cases. It is not clear if the development of pyoderma gangrenosum correlates with severity or flares of inflammatory bowel disease.
How fast do pyoderma gangrenosum ulcers develop?
Pyoderma gangrenosum ulcers can develop quickly. They usually clear up with treatment, but scarring and recurrences are common. Pyoderma gangrenosum usually starts with a small, red bump on your skin, which may resemble a spider bite. Within days, this bump can develop into a large, painful open sore.
Significance:Pyoderma gangrenosum (PG) is a rare neutrophilic ulcerative dermatosis that poses a high burden of morbidity due to underdiagnosis, resistance to therapy, and limited therapeutic options.
How are corticosteroids administered in the treatment of pyoderma gangrenosum (mg)?
Corticosteroids may be administered by intramuscular injection or orally or by intralesional injection directly into the pyoderma gangrenosum.
What is the difference between classic and atypical pyoderma gangrenosum?
Some cases that have been called atypical pyoderma gangrenosum actually represent Sweet syndrome. Classic pyoderma gangrenosum is often characterized by the presence of pus and can begin with pustules. Pustular pyoderma gangrenosum is characterized by painful bumps (pustules) most often found on the arms and legs.