Innehållsförteckning
Vad är PGE2?
Pyrogen är ett ämne som är feberframkallande. Pyrogener leder till att kroppen utsöndrar substansen prostaglandin E2 (PGE2). PGE2 agerar i sin tur på hypotalamus som får kroppen att reagera och inducera feber. En pyrogen kan vara antingen intern (endogen) eller extern (exogen) till kroppen.
Vad är cox-1 och cox-2?
Det finns två varianter av COX; COX-1 som uttrycks konstitutivt i de flesta celler och COX-2 som induceras vid inflammation. Såväl COX-1 som COX-2 bildar prostaglandiner, som ökar smärtsignaleringen såväl i periferin som i ryggmärgens bakhorn [1].
Vad gör Cox 1?
What is the role of PGE2 in inflammation?
Multifaceted roles of PGE2 in inflammation. The inflammatory response is comprised of a finely orchestrated set of interconnected processes, involving a diversity of cell types and inflammatory mediators. PGE2 plays a critical role in guiding and governing various aspects of the inflammatory response.
What is prostaglandin E2 (PGE2)?
Prostaglandin E2 (PGE2) is one of the most typical lipid mediators produced from arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on four kinds of receptor subtypes (EP1-EP4) to elicit its diverse actions including pyrexia, pain sensation, and inflammation.
What are the primary prostaglandins found in inflammation?
The primary prostaglandins such as PGE2, as well as the breakdown products of prostacyclin and TxA2, have all been detected in elevated levels at sites of acute and chronic inflammation. The most abundant cyclo-oxygenase product is usually PGE2, but this depends on the nature and location of the inflammatory response.
Is pge2formation targeted in the context of IBD-related cancer?
Thus, targeting PGE2formation within the context of IBD-related cancers presents an important clinical challenge and underscores a key paradox for successful clinical management.