What is Staphylococcus epidermidis?

What is Staphylococcus epidermidis?

What is Staphylococcus epidermidis? Staphylococcus epidermidis is a Gram-positive bacterium belonging to the genus Staphylococcus and is the most frequently isolated species from human epithelia.

Does a commensal strain of Staphylococcus epidermidis protect against skin neoplasia?

”A commensal strain of Staphylococcus epidermidis protects against skin neoplasia”. Science Advances. 4 (2): eaao4502. Bibcode: 2018SciA….4.4502N. doi: 10.1126/sciadv.aao4502.

Is Staphylococcus epidermidis a facultative anaerobe?

S. epidermidis is a facultative anaerobe but also grows well under aerobic conditions ( Figure 3.11 (C) and (D) ). Culture conditions for S. epidermidis are similar to those of S. aureus (see 5.1.1.1 ), but S. epidermidis grows slowly in medium with 10% NaCl.

Is Staphylococcus epidermidis coagulase negative?

S. epidermidis is the predominant coagulase-negative Staphylococcus species found in the material of human origin. Humans are the only natural host for this organism. The physiological habitat of S. epidermidis is the skin and mucous membranes of humans and animals.

A colorized scanning electron micrograph of Staphylococcus epidermidis (green) and extracellular matrix (purple) Staphylococcus epidermidis is a normal component of our skin and mucous membrane flora and often causes no problems. It may even help us. Under certain conditions, however, it produces harmful and sometimes deadly infections.

Why is Staphylococcus epidermidis resistant to antibiotics?

They are sometimes a major problem. Even when it’s not in a biofilm, Staphylococcus epidermidis is resistant to many antibiotics. Researchers have discovered that strains with a high tendency to form biofilms have a higher degree of antibiotic resistance than those with a low tendency.

Why is Staphylococcus epidermidis called a facultative anaerobe?

The species name refers to the fact that the bacterium is often found on the outer layer of the skin, or the epidermis. S. epidermidis survives with or without oxygen and is therefore said to be a facultative anaerobe.

This bacterium is known as the major cause of medical implant device infections such as peripheral or central intravenous catheters (CVCs) [54]. In accordance to performed researches in United States, at least 5 cases of bloodstream infections of 1,000 CVC in ICU, the 22% of mentioned infections are correlated by Staphylococcus epidermidis[54].

Is Staphylococcus epidermidis coagulase positive or negative?

Staphylococcus epidermidiswith the highest percentage has the prominent role among coagulase-negative Staphylococci that is the most important reason of clinical infections. Due to various virulence factors and unique features, this microorganism is respected as a common cause of nosocomial infections.

Why is Staphylococcus epidermidis considered a biomaterial-associated infection?

Apparently Staphylococcus epidermidisis regarded as one of the most biomaterial-associated infection (BAI) reasons. Also extracellular polysaccharides production and biofilm formation increase the bacterial stability on different surfaces therefore the antibiotic penetration will be prevented [73].

How does Staphylococcus epidermidis protect itself from neutrophils?

Recently is shown that S. epidermidis biofilm contains a large number of persistent cells that protect the microorganism against neutrophil dependent killing and complement system inactivation via deposition of C3b and immunoglobulin G [10].

Staphylococci are common bacterial colonizers of the skin and mucous membranes of humans and other mammals 4. S. epidermidis in particular is the most frequently isolated species from human epithelia.

Are people with Staphylococcus epidermidis opportunists?

They do people are classic opportunists, only possess a low pathogenic potential for immune-competent individuals. Staphylococcus epidermidis is responsible for 70-80% of infections caused by CNS.

Is Staphylococcus epidermidis a contaminant in urine culture?

When Staphylococcus epidermidis is isolated in urine culture, it is assumed to be a contaminant. As demonstrated in the following case, however, this assumption should not be made in a symptomatic child for whom an alternate source of infection cannot be identified.

Is Staphylococcus epidermidis a virulence determinant?

While nosocomial infections by Staphylococcus epidermidis have gained much attention, this skin colonizer has apparently not evolved to cause disease, but maintain the commonly benign relationship with its host. Accordingly, S. epidermidis does not produce aggressive virulence determinants.

What causes Staphylococcus epidermidis resistant to methicillin?

Staphylococcus epidermidis–hospital epidemiology and the detection of methicillin resistance Infections in immunocompromised patients and in patients with indwelling prosthetic devices are often caused by hospital strains of Staphylococcus epidermidis resistant to methicillin.

Is S epidermidis Gram positive or negative?

S. epidermidis is a Gram-positive bacterium that appears spherical with an average diameter of 0.5–1.5 µm on light microscopy. The cells of old cultures (>48 h) are often gram-variable to nearly gram-negative. Cells divide in more than one plane to form irregular clusters and aggregates of pairs, tetrads, and short chains.